Standardised and Reproducible Phenotyping Using Distributed Analytics and Tools in the Data Analysis and Real World Interrogation Network (<scp>DARWIN EU</scp>)
Our detailed phenotyping process makes use of bespoke tools and allows for comprehensive codelist generation and review, as well as large-scale exploration of the characteristics of the resulting cohorts. Wider use of structured and reproducible phenotyping methods will be important in ensuring the reliability of observational studies for regulatory purposes.
Authors
- Luís Pinheiro (ORCID: https://orcid.org/0000-0002-6253-7175)
- Albert Prats‐Uribe (ORCID: https://orcid.org/0000-0003-1202-9153)
- Guillaume Verdy
- Miguel Ángel Mayer (ORCID: https://orcid.org/0000-0003-0362-6298)
- Katia M.C. Verhamme (ORCID: https://orcid.org/0000-0001-8162-4904)
- James T. Brash
- Daniel R. Morales (ORCID: https://orcid.org/0000-0002-0063-8069)
- Ángela Leis (ORCID: https://orcid.org/0000-0003-4780-7111)
- Daniel Prieto‐Alhambra (ORCID: https://orcid.org/0000-0002-3950-6346)
- Peter R. Rijnbeek (ORCID: https://orcid.org/0000-0003-0621-1979)
- Juan Manuel Ramírez‐Anguita (ORCID: https://orcid.org/0000-0002-8509-0927)
- Francesco Dernie (ORCID: https://orcid.org/0000-0001-5344-1967)
- Annika M. Jödicke (ORCID: https://orcid.org/0000-0002-0000-0110)
- Talita Duarte‐Salles (ORCID: https://orcid.org/0000-0002-8274-0357)
- Alexandra C. Pacurariu (ORCID: https://orcid.org/0000-0002-2217-0540)
- Romain Griffier (ORCID: https://orcid.org/0000-0002-1096-137X)
- Rowan Parry
- Núria Mercadé‐Besora (ORCID: https://orcid.org/0009-0006-7948-3747)
- George Corby (ORCID: https://orcid.org/0000-0002-5057-2985)
- James Bezer
- Sarah Seager
- Abigail Robinson
Institutions
- Universitat Autònoma de Barcelona (ES)
- European Medicines Agency (NL)
- University of Dundee (GB)
- Nuffield Orthopaedic Centre (GB)
- IQVIA (United Kingdom) (GB)
- University of Oxford (GB)
- Institut Universitari d'Investigació en Atenció Primària Jordi Gol (ES)
- Hospital Del Mar (ES)
- Parc de Salut (ES)
- Genomics (United Kingdom) (GB)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Pharmacoepidemiology and Drug Safety
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1002/pds.70042
- Citations
- 15
- Primary Topic
- Statistical Methods in Clinical Trials
- Type
- article
- Field-Weighted Citation Impact
- 10.64
Funders
- National Institute for Health and Care Research
- European Medicines Agency
- NIHR Oxford Biomedical Research Centre