Plasma Alzheimer's disease biomarker variability: Amyloid‐independent and amyloid‐dependent factors
We investigated factor-Alzheimer's disease plasma biomarker associations in a large Korean cohort. Hemoglobin and estimated glomerular filtration rate affect the biomarkers independently of brain amyloid beta (Aβ). Apolipoprotein E genotypes and body mass index status affect the biomarkers dependent on brain Aβ. Addition of Aβ-independent factors shows negligible effect in predicting Aβ positivity. Adjusting for Aβ-dependent factors shows a modest effect in predicting Aβ positivity.
Authors
- Jun Pyo Kim (ORCID: https://orcid.org/0000-0003-4376-3107)
- Bo Kyoung Cheon (ORCID: https://orcid.org/0000-0002-5613-517X)
- Duk Lyul Na (ORCID: https://orcid.org/0000-0002-0098-7592)
- Jihwan Yun
- Fernando González‐Ortiz (ORCID: https://orcid.org/0000-0001-7897-9456)
- Hongki Ham (ORCID: https://orcid.org/0009-0002-0806-6453)
- Hyemin Jang (ORCID: https://orcid.org/0000-0003-3152-1274)
- Kaj Blennow
- Sang Won Seo (ORCID: https://orcid.org/0000-0002-8747-0122)
- Sung Hoon Kang (ORCID: https://orcid.org/0000-0002-2481-0302)
- Hee Jin Kim (ORCID: https://orcid.org/0000-0002-3186-9441)
- Heejin Yoo (ORCID: https://orcid.org/0000-0003-4341-6906)
- Young Ju Kim (ORCID: https://orcid.org/0000-0003-2927-6724)
- Eun Hye Lee (ORCID: https://orcid.org/0000-0003-2570-3442)
- Daeun Shin (ORCID: https://orcid.org/0000-0003-4834-1026)
- Nicholas J. Ashton
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0002-4671-6763)
Institutions
- University of Science and Technology of China (CN)
- University of Wisconsin–Madison (US)
- King's College London (GB)
- Soonchunhyang University (KR)
- Korea University Medical Center (KR)
- Stavanger University Hospital (NO)
- Sahlgrenska University Hospital (SE)
- Samsung Medical Center (KR)
- Seoul National University Hospital (KR)
- Centre for Mental Health (GB)
- Sorbonne Université (FR)
- Pitié-Salpêtrière Hospital (FR)
- UK Dementia Research Institute (GB)
- Institut du Cerveau (FR)
- University College London (GB)
- Bucheon University (KR)
- Sungkyunkwan University (KR)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1002/alz.14368
- Citations
- 16
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.22
Funders
- Alzheimer's Association
- EU Joint Programme – Neurodegenerative Disease Research
- Korea University Guro Hospital
- European Commission
- National Research Foundation
- Korea University
- National Research Foundation of Korea
- Hjärnfonden
- Vetenskapsrådet
- Kirsten og Freddy Johansens Fond
- Ministry of Science and ICT, South Korea
- Fondation pour la Recherche sur Alzheimer
- Samsung
- Korea National Institute of Health