Large‐scale deep proteomic analysis in Alzheimer's disease brain regions across race and ethnicity
We present a large-scale proteome (∼10,000 proteins) of DLPFC (998) and STG (244) across AD cases. About 50% of samples were from racially and ethnically diverse brain donors. Key AD proteins (amyloid and tau) correlated with CERAD and Braak stages. No significant race-related differences in amyloid and tau protein levels were observed in AD brains. AD-associated protein changes showed a strong correlation between the brain proteomes of African American and White individuals. This dataset advances understanding of ethnoracial-specific AD pathways and potential therapies.
Authors
- Alexi Runnels (ORCID: https://orcid.org/0000-0002-8592-1444)
- Adriana O. Mitchell
- Dennis W. Dickson (ORCID: https://orcid.org/0000-0001-7189-7917)
- Joseph S. Reddy (ORCID: https://orcid.org/0000-0002-1783-4453)
- Abby Vander Linden (ORCID: https://orcid.org/0000-0003-1932-2483)
- Nicholas T. Seyfried (ORCID: https://orcid.org/0000-0002-4507-624X)
- Allan I. Levey (ORCID: https://orcid.org/0000-0002-3153-502X)
- Lisa L. Barnes (ORCID: https://orcid.org/0000-0002-0072-9817)
- Erming Wang (ORCID: https://orcid.org/0009-0000-8056-0785)
- Jo Scanlan
- Thomas Beach (ORCID: https://orcid.org/0000-0001-5610-8027)
- Erica Modeste (ORCID: https://orcid.org/0000-0002-2072-129X)
- Charlotte C.G. Ho (ORCID: https://orcid.org/0000-0002-9135-1652)
- Philip L. De Jager (ORCID: https://orcid.org/0000-0002-8057-2505)
- Geidy E. Serrano (ORCID: https://orcid.org/0000-0002-9527-2011)
- Eric B. Dammer (ORCID: https://orcid.org/0000-0003-2947-7606)
- Minerva M. Carrasquillo (ORCID: https://orcid.org/0000-0002-3231-9134)
- Fatemeh Seifar (ORCID: https://orcid.org/0000-0003-0387-6991)
- Todd Eliot Golde (ORCID: https://orcid.org/0000-0003-1867-7071)
- Lingyan Ping
- Edward B. Lee (ORCID: https://orcid.org/0000-0002-4589-1180)
- Marla Gearing (ORCID: https://orcid.org/0000-0002-1959-7412)
- Luming Yin
- William L. Poehlman (ORCID: https://orcid.org/0000-0002-3659-9663)
- Laura Heath (ORCID: https://orcid.org/0000-0002-0318-2773)
- Anantharaman Shantaraman (ORCID: https://orcid.org/0000-0003-1384-941X)
- Nilüfer Ertekin‐Taner (ORCID: https://orcid.org/0000-0003-4436-8889)
- Stephanie R. Oatman
- Mariet Allen (ORCID: https://orcid.org/0000-0002-2685-427X)
- Zachary Quicksall (ORCID: https://orcid.org/0000-0002-8791-0925)
- Stefan Prokop (ORCID: https://orcid.org/0000-0002-5633-2149)
- Aliza P. Wingo (ORCID: https://orcid.org/0000-0002-6360-6726)
- Adam N. Trautwig
- Geovanna Yepez
- Yue Liu (ORCID: https://orcid.org/0000-0002-5625-0602)
- Minghui Wang (ORCID: https://orcid.org/0000-0001-9171-4962)
- Bin Zhang (ORCID: https://orcid.org/0000-0002-5591-7874)
- Xue Wang (ORCID: https://orcid.org/0009-0009-3062-2103)
- David A. Bennett
- Xianfeng Chen (ORCID: https://orcid.org/0000-0002-7531-5862)
- Edward J. Fox
- Thuy Nguyen (ORCID: https://orcid.org/0000-0003-2971-4077)
- Duc M. Duong (ORCID: https://orcid.org/0000-0002-3325-9233)
- Anna Greenwood (ORCID: https://orcid.org/0000-0003-0605-431X)
- Thomas S. Wingo (ORCID: https://orcid.org/0000-0002-7679-6282)
- Qi Guo (ORCID: https://orcid.org/0000-0003-2244-2101)
- Kaiming Xu
- James J. Lah (ORCID: https://orcid.org/0000-0002-8810-620X)
- V. Haroutunian
- Saurabh Baheti (ORCID: https://orcid.org/0000-0002-3564-7627)
Institutions
- Rush University Medical Center (US)
- Sage Bionetworks (US)
- Emory University (US)
- Columbia University Irving Medical Center (US)
- Jacksonville College (US)
- University of Florida (US)
- Institute for Neurodegenerative Disorders (US)
- Banner Sun Health Research Institute (US)
- Mayo Clinic in Florida (US)
- New York Genome Center (US)
- University of Pennsylvania (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1002/alz.14360
- Citations
- 37
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 12.08
Funders
- National Institute on Aging