The mediating role of plasma glial fibrillary acidic protein in amyloid and tau pathology in Down's syndrome
Amyloid may be a necessary precursor for stimulating astrocytes. Astrogliosis may play a key role in modifications to tau phosphorylation. Targeting neuroinflammation may only aid amyloid positive individuals. Alzheimer's disease timecourse is compressed in individuals with Down's syndrome.
Authors
- Dana Tudorascu (ORCID: https://orcid.org/0000-0003-4675-3692)
- Benjamin L. Handen (ORCID: https://orcid.org/0000-0001-9550-1665)
- Adam M. Brickman (ORCID: https://orcid.org/0000-0002-5125-8226)
- Sharon J. Krinsky‐McHale (ORCID: https://orcid.org/0000-0002-7205-7319)
- Joseph Hyungwoo Lee (ORCID: https://orcid.org/0000-0002-2000-4821)
- Michael S. Rafii (ORCID: https://orcid.org/0000-0003-2640-2094)
- Matthew Zammit (ORCID: https://orcid.org/0000-0001-8966-8397)
- Julie K. Wisch (ORCID: https://orcid.org/0000-0003-3624-2784)
- Shahid Zaman (ORCID: https://orcid.org/0000-0003-1639-6014)
- Sid E. O’Bryant (ORCID: https://orcid.org/0000-0003-0582-5266)
- Florence Lai (ORCID: https://orcid.org/0000-0003-4354-0624)
- Anna H. Boerwinkle (ORCID: https://orcid.org/0000-0001-7107-3651)
- Elizabeth Head (ORCID: https://orcid.org/0000-0003-1115-6396)
- Beau M. Ances (ORCID: https://orcid.org/0000-0003-3862-7397)
- Mark E. Mapstone (ORCID: https://orcid.org/0000-0003-0280-8057)
- Ira T. Lott (ORCID: https://orcid.org/0000-0002-3107-0752)
- H. Diana Rosas
Institutions
- University of North Texas (US)
- Autism Research Institute (US)
- University of Wisconsin–Madison (US)
- Harvard University (US)
- University of North Texas Health Science Center (US)
- University of Pittsburgh (US)
- University of California, Irvine (US)
- Washington University in St. Louis (US)
- University of Cambridge (GB)
- Columbia University Irving Medical Center (US)
- New York State Office for People With Developmental Disabilities (US)
- Massachusetts General Hospital (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1002/alz.14359
- Citations
- 10
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.27
Funders
- Foundation for Barnes-Jewish Hospital
- Hope Center for Neurological Disorders
- National Institute on Aging
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development