Melatonin attenuates degenerative disc degression by downregulating <scp>DLX5</scp> via the <scp>TGF</scp>/Smad2/3 pathway in nucleus pulposus cells
DLX5 plays an important role in IVDD progression by promoting apoptosis, and melatonin represents a promising therapeutic strategy for alleviating IVDD-associated inflammation and apoptosis.
Authors
- Ling Mo (ORCID: https://orcid.org/0000-0003-4452-4757)
- Kuibo Zhang
- Chao Yuan (ORCID: https://orcid.org/0000-0002-4719-9702)
- Caijun Liu (ORCID: https://orcid.org/0009-0008-2370-1623)
- Hua Wang (ORCID: https://orcid.org/0000-0002-2605-5697)
- Xiaohui Huang (ORCID: https://orcid.org/0000-0002-5309-0770)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Sun Yat-sen University (CN)
- Fifth Affiliated Hospital of Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- The Third Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- JOR Spine
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1002/jsp2.70014
- Citations
- 3
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.27