Enhancing Antibacterial Efficacy: Combining Novel Bacterial Topoisomerase Inhibitors with Efflux Pump Inhibitors and Other Agents Against Gram-Negative Bacteria
These results show for the first time that combinations of NBTIs with either EPIs or a different class of the topoisomerase inhibitors may be a beneficial strategy to combat difficult-to-treat bacterial infections.
Authors
- Irena Zdovc
- Marko Anderluh (ORCID: https://orcid.org/0000-0003-1768-8246)
- Martina Hrast (ORCID: https://orcid.org/0000-0003-0488-2445)
- Nikola Minovski (ORCID: https://orcid.org/0000-0003-0039-2246)
- Lucíja Peterlin Mašič (ORCID: https://orcid.org/0000-0003-0624-8472)
- Mina Mandic (ORCID: https://orcid.org/0000-0002-3246-6230)
- Maša Zorman
- Martina Durcik (ORCID: https://orcid.org/0000-0002-9218-1771)
- Andrej Emanuel Cotman (ORCID: https://orcid.org/0000-0003-2528-396X)
- Maja Kokot (ORCID: https://orcid.org/0000-0002-9307-330X)
- Lidija Šenerović (ORCID: https://orcid.org/0000-0002-6965-9407)
- Nace Zidar (ORCID: https://orcid.org/0000-0003-1905-0158)
Institutions
- University of Ljubljana (SI)
- University of Belgrade (RS)
- National Institute of Chemistry (SI)
Publication Details
- Journal
- Antibiotics
- Published
- 2024-11-13
- DOI
- https://doi.org/10.3390/antibiotics13111081
- Citations
- 1
- Primary Topic
- Cancer therapeutics and mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- Javna Agencija za Raziskovalno Dejavnost RS