Genetic Influence of the Brain on Muscle Structure: A Mendelian Randomization Study of Sarcopenia
We discovered the causal effect of BIDs and brain gene expression on sarcopenia. The positive genes were mainly enriched in immune-related signalling, suggesting an immune-based cross-organ regulation mechanism of brain-muscle axis.
Authors
- Jing Nan (ORCID: https://orcid.org/0000-0002-2635-5219)
- Zewu Zhu (ORCID: https://orcid.org/0000-0001-5320-9391)
- Hua Long (ORCID: https://orcid.org/0000-0002-1858-7108)
- Yihe Hu (ORCID: https://orcid.org/0000-0002-1340-1474)
- Ting Lei (ORCID: https://orcid.org/0000-0003-3241-7567)
- Zichao Jiang
- Jiahao Wang (ORCID: https://orcid.org/0009-0008-6878-3597)
Institutions
- Central South University (CN)
- Xinjiang Medical University (CN)
- Nankai University (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
- Xiangya Hospital Central South University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1002/jcsm.13647
- Citations
- 4
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 1.31
Funders
- National Natural Science Foundation of China