Effect and mechanism of Tetramethylpyrazine in repair of sciatic nerve injury in rats
TMP can effectively improve the sciatic nerve functional index (SFI) of Sprague Dawley (SD) rats, enhance the proliferation of sciatic nerve vascular endothelial cells, reduce apoptosis, promote the expression of Collagen IV and Laminin in sciatic nerve microvascular basal membrane components, thereby promoting angiogenesis and improving lower limb function in rats.
Authors
- Li Yao (ORCID: https://orcid.org/0000-0002-2337-799X)
- Yujie Li (ORCID: https://orcid.org/0000-0002-7256-6025)
- Li Yang (ORCID: https://orcid.org/0000-0002-5484-0895)
- Naiqiang Zhuo (ORCID: https://orcid.org/0000-0002-5988-8361)
- Guan Wang (ORCID: https://orcid.org/0000-0003-1822-729X)
Institutions
- Southwest Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
Publication Details
- Journal
- BMC Neuroscience
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1186/s12868-024-00897-6
- Citations
- 1
- Primary Topic
- Plant-based Medicinal Research
- Type
- article
- Field-Weighted Citation Impact
- 0.47