Utilization of Tin(IV) Complex of N‐Confused Porphyrin for Antiproliferative Activity and Antimicrobial Photodynamic Chemotherapy

Sn(IV) complex of N-Confused Porphyrin (Sn(IV)-NCP) has been prepared and characterized by several spectroscopic techniques to verify its structure and purity. Sn(IV)-NCP shows a red shift in both the Soret and Q bands compared to the free base NCTPP. The last Q band appears in the NIR region. Based on these characteristics, we investigated the antiproliferative properties and antimicrobial photodynamic therapy (a-PDT) efficiency of Sn(IV)-NCP against the bacteria Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Further, we investigated the photodynamic activity of Sn (IV)-NCP against Michigan cancer foundation-7 (MCF-7) cancer cells, to assess its potential as an effective therapeutic agent. Treated MCF-7 cells with the compound show cytotoxic effects as compared to the untreated ones. At a higher concentration (128 μg/ml), Sn(IV)-NCP exhibited 90 % inhibition, while at a lower concentration (32 μg/ml), it showed 70 % inhibition in MCF-7 cells. The IC₅₀ value for this compound against MCF-7 cells was found 16.67 μg/ml. At 32 μg/ml, Sn(IV)-NCP showed only around 4 % cell inhibition, indicating minimal cytotoxic effects on human embryonic kidney cells (HEK293).