Cryo-thermal therapy reshaped the tumor immune microenvironment to enhance the efficacy of adoptive T cell therapy
Our results suggest that CTT can significantly reshape the tumor immunosuppressive microenvironment and convert "cold tumors" into "hot tumors," thereby enhancing ACT-induced immune responses and maximizing the therapeutic effect of ACT.
Authors
- Lisa X. Xu (ORCID: https://orcid.org/0000-0003-2873-3225)
- Zelu Zhang
- Peng Peng (ORCID: https://orcid.org/0000-0002-8341-3008)
- Junjun Wang (ORCID: https://orcid.org/0000-0001-7038-2743)
- Ping Liu (ORCID: https://orcid.org/0000-0003-1662-1410)
- Shicheng Wang (ORCID: https://orcid.org/0000-0003-3819-9660)
Institutions
- Shanghai Jiao Tong University (CN)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1007/s00262-024-03884-2
- Citations
- 4
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 1.13
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- National Key Research and Development Program of China