Comparison of the dosimetry and cell survival effect of 177Lu and 161Tb somatostatin analog radiopharmaceuticals in cancer cell clusters and micrometastases
Despite the emissions of IE and AE from <sup>161</sup>Tb-RPs, their localization within different subcellular regions exerted a negligible influence on the AD<sub>N</sub>. The same cell damage produced by <sup>177</sup>Lu-RPs could be achieved using smaller quantities of <sup>161</sup>Tb-RPs, thus making <sup>161</sup>Tb a suitable alternative for TRT.
Authors
- Guillermina Ferro‐Flores (ORCID: https://orcid.org/0000-0003-0296-7605)
- Laura De Nardo (ORCID: https://orcid.org/0000-0002-0061-370X)
- Vito Barbieri (ORCID: https://orcid.org/0000-0002-8349-6704)
- Antonio Rosato (ORCID: https://orcid.org/0000-0002-5263-8386)
- Alessandra Zorz (ORCID: https://orcid.org/0000-0001-5650-9832)
- Laura Meléndez‐Alafort (ORCID: https://orcid.org/0000-0003-0701-3616)
- Anna Dalla Pietà (ORCID: https://orcid.org/0000-0002-7875-7914)
- Erika Azorín‐Vega (ORCID: https://orcid.org/0000-0002-7520-461X)
- S. Santi
- Emma Nascimbene
Institutions
- University of Padua (IT)
- Instituto Nacional de Investigaciones Nucleares (MX)
- Istituto Oncologico Veneto (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- EJNMMI Physics
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1186/s40658-024-00696-2
- Citations
- 5
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.02
Funders
- Ministero della Salute
- International Atomic Energy Agency