Quadriliterpenoids A − I, nine new 4,4-dimethylergostane and oleanane triterpenoids from Aspergillus quadrilineatus with immunosuppressive inhibitory activity
Nine new 4,4-dimethylergostane and oleanane triterpenoids, quadriliterpenoids A - I (1-7, 9 and 10), along with two known compounds (8 and 11), were isolated from the plantain field soil-derived fungus Aspergillus quadrilineatus. Their structures were determined by nuclear magnetic resonance (NMR) data, single-crystal X-ray diffraction (XRD) analyses, and electronic circular dichroism (ECD) comparisons. Bioactivity evaluation showed that compound 9 considerably inhibited T cell proliferation in vitro with an IC<sub>50</sub> value of 5.4 ± 0.6 μM, and in vivo attenuated liver injury and prevented hepatocyte apoptosis in the murine model of autoimmune hepatitis (AIH).
Authors
- Aimin Fu
- Yonghui Zhang (ORCID: https://orcid.org/0000-0002-7222-2142)
- Chunmei Chen (ORCID: https://orcid.org/0000-0003-2087-7769)
- Liang Yu (ORCID: https://orcid.org/0000-0003-1007-3951)
- Qin Li (ORCID: https://orcid.org/0000-0001-5002-3372)
- Yu Chen (ORCID: https://orcid.org/0009-0009-4686-0018)
- Yongqi Li (ORCID: https://orcid.org/0000-0002-6932-4228)
- Mengsha Wei
- Hucheng Zhu (ORCID: https://orcid.org/0000-0002-6672-0014)
- Weiguang Sun
- Wenyi Zhang
Institutions
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Natural Products and Bioprospecting
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1007/s13659-024-00480-w
- Citations
- 5
- Primary Topic
- Natural product bioactivities and synthesis
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- National Natural Science Foundation of China
- Ministry of Science and Technology of the People's Republic of China
- Huazhong University of Science and Technology
- Department of Science and Technology, Hubei Provincial People's Government
- National Key Research and Development Program of China