Prevention and Treatment of Cancer-Related Infections, Version 3.2024, NCCN Clinical Practice Guidelines in Oncology
There is an increased risk of infection in patients with cancer that results in higher morbidity and mortality. Several risk factors can predispose these patients to infectious complications. Some such factors include immunocompromised states like neutropenia, allogeneic hematopoietic cell transplantation, and graft-versus-host disease, while others include immunosuppressive agents like corticosteroids, purine analogs, monoclonal antibodies, and other emerging cancer therapeutics like CAR T-cell therapy. The NCCN Guidelines for the Prevention and Treatment of Cancer-Related Infections address infection concerns that may be observed in these immunocompromised populations and characterize the major pathogens to which patients with cancer are susceptible, with a focus on the prevention, diagnosis, and treatment of major common and opportunistic infections. This paper highlights 2 recently updated sections of the guidelines, namely, infection concerns related to CAR T-cell therapy and antimicrobial prophylaxis recommendations, including vaccination, in patients at high-risk for infections.
Authors
- Susan K. Seo (ORCID: https://orcid.org/0000-0002-3370-4691)
- Randy Taplitz (ORCID: https://orcid.org/0000-0002-0109-5991)
- Kristen Manley
- Sankar Swaminathan (ORCID: https://orcid.org/0000-0002-9773-1277)
- Brenda Cooper (ORCID: https://orcid.org/0000-0001-9376-9377)
- Kevin Gregg (ORCID: https://orcid.org/0000-0003-3661-2490)
- Jeffrey Topal (ORCID: https://orcid.org/0000-0003-4308-2352)
- Carly J. Cassara
- Fareed Khawaja (ORCID: https://orcid.org/0000-0003-4424-283X)
- Mindy G. Schuster (ORCID: https://orcid.org/0009-0002-0597-7411)
- Nicolas Barros (ORCID: https://orcid.org/0000-0002-8531-3537)
- Hana Hakim (ORCID: https://orcid.org/0000-0001-7146-5452)
- Zeinab El Boghdadly
- Shmuel Shoham (ORCID: https://orcid.org/0000-0001-7276-7786)
- Anupam Pande (ORCID: https://orcid.org/0000-0001-8024-925X)
- Aliyah Baluch (ORCID: https://orcid.org/0000-0001-6704-7055)
- Michael Angarone (ORCID: https://orcid.org/0000-0002-3728-7864)
- Augusto Dulanto Chiang (ORCID: https://orcid.org/0000-0001-8040-9620)
- Jennifer L. Saullo (ORCID: https://orcid.org/0000-0002-7684-431X)
- Steven A. Pergam (ORCID: https://orcid.org/0000-0002-6333-5196)
- John Wilson (ORCID: https://orcid.org/0000-0003-2118-3646)
- Andrea Zimmer (ORCID: https://orcid.org/0000-0002-1460-0774)
- Francesca Lee (ORCID: https://orcid.org/0000-0003-4707-953X)
- Ashrit Multani (ORCID: https://orcid.org/0000-0003-4043-4287)
- Rashmi Kumar (ORCID: https://orcid.org/0000-0001-8994-5091)
- Cathy Logan (ORCID: https://orcid.org/0000-0002-3895-952X)
- Dora Y. Ho (ORCID: https://orcid.org/0000-0003-0709-2414)
- Jennifer Pisano (ORCID: https://orcid.org/0000-0002-8156-3731)
- Brian Buss
- Nikolaos G. Almyroudis (ORCID: https://orcid.org/0000-0002-4230-3275)
- Lindsey Robert Baden (ORCID: https://orcid.org/0009-0004-1752-1926)
- Zeenat Diwan
- Rachael Lee (ORCID: https://orcid.org/0000-0001-9844-941X)
- Stuart H. Cohen
Institutions
- Fox Chase Cancer Center (US)
- Roswell Park Comprehensive Cancer Center (US)
- City Of Hope National Medical Center (US)
- St. Jude Children's Research Hospital (US)
- Cleveland Clinic (US)
- Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA)
- Memorial Sloan Kettering Cancer Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- Breast Cancer Research Foundation (US)
- University of Utah (US)
- The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US)
- UC San Diego Health System (US)
- Huntsman Cancer Institute (US)
- Cancer Institute (WIA) (IN)
- Susan Thompson Buffett Foundation (US)
- WinnMed (US)
- Yale Cancer Center (US)
- Moffitt Cancer Center (US)
- Fred Hutch Cancer Center (US)
- Southwestern Medical Center (US)
- University of Wisconsin Carbone Cancer Center (US)
- Sidney Kimmel Cancer Center (US)
- Dana-Farber Cancer Institute (US)
- University Hospitals Seidman Cancer Center (US)
- Duke Medical Center (US)
- University of Colorado Cancer Center (US)
- Smilow Cancer Hospital (US)
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- Indiana University Melvin and Bren Simon Comprehensive Cancer Center
- Moores Cancer Center
- University of Chicago Medicine Comprehensive Cancer Center
- UCLA Jonsson Comprehensive Cancer Center
- Vanderbilt-Ingram Cancer Center
- Stanford Cancer Institute
- Duke Cancer Institute
- Fred and Pamela Buffett Cancer Center
- UC Davis Comprehensive Cancer Center
- Harold C. Simmons Comprehensive Cancer Center
- O'Neal Comprehensive Cancer Center
- National Comprehensive Cancer Network
- Indiana University (US)
- University of Pennsylvania (US)
- University of California, Davis (US)
- The University of Texas Southwestern Medical Center (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Journal of the National Comprehensive Cancer Network
- Published
- 2024-11-01
- DOI
- https://doi.org/10.6004/jnccn.2024.0056
- Citations
- 44
- Primary Topic
- Neutropenia and Cancer Infections
- Type
- article
- Field-Weighted Citation Impact
- 11.58