Hyperresponsiveness of Corticoid-Resistant Th17/Tc-17 Cells to TLR-2 and TLR-4 Ligands is a Feature of Multiple Sclerosis Patients at Higher Risk of Therapy Failure
Collectively, the data suggested that persistence of circulating Th17 and Tc17 cells expressing elevated levels of functional TLR-2 and TLR-4 could indicate high disease activity and lower therapeutic efficacy in RRMS patients.
Authors
- Joana Hygino (ORCID: https://orcid.org/0000-0002-5934-8779)
- Cláudia Cristina Ferreira Vasconcelos (ORCID: https://orcid.org/0000-0003-0833-4024)
- Priscila M. Sacramento (ORCID: https://orcid.org/0000-0003-0788-3195)
- Marisa C. Sales
- Cleonice A.M. Bento (ORCID: https://orcid.org/0000-0002-8613-6608)
- Taissa M. Kasahara
- Júlio César Costa da Silva (ORCID: https://orcid.org/0009-0008-6503-9869)
- Regis M. Andrade
- Rafaela Bilhão
Institutions
- Universidade Federal do Rio de Janeiro (BR)
- Universidade do Estado do Rio de Janeiro (BR)
- Universidade Federal do Estado do Rio de Janeiro (BR)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2024-11-01
- DOI
- https://doi.org/10.2147/jir.s476110
- Citations
- 1
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro