Hypoxia‐reduced <scp>YAP</scp> phosphorylation enhances expression of <scp>Mucin5AC</scp> in nasal epithelial cells of chronic rhinosinusitis with nasal polyps
Our findings indicated that hypoxia enhances YAP activation by decreasing p-LATS 1 and YAP phosphorylation. This has the potential to impact on the proliferation of basal cells and the differentiation of goblet cells in CRSwNP, ultimately leading to a pathological condition characterized by excessive Mucin5AC expression.
Authors
- Hsiao Hui Ong (ORCID: https://orcid.org/0000-0002-9753-2059)
- Yafeng Liu (ORCID: https://orcid.org/0000-0003-3930-4872)
- Luo Ba (ORCID: https://orcid.org/0000-0003-2306-6224)
- Bing Zhong (ORCID: https://orcid.org/0009-0007-6654-4106)
- De Yun Wang (ORCID: https://orcid.org/0000-0002-0909-2963)
- Feng Liu (ORCID: https://orcid.org/0000-0002-9894-4362)
- Jintao Du (ORCID: https://orcid.org/0000-0001-8552-5508)
- Silu Sun (ORCID: https://orcid.org/0000-0002-5947-9648)
- Jing Liu (ORCID: https://orcid.org/0000-0002-9377-1626)
Institutions
- National University of Singapore (SG)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Tibet Autonomous Region People's Hospital (CN)
Publication Details
- Journal
- Allergy
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1111/all.16394
- Citations
- 7
- Primary Topic
- Sinusitis and nasal conditions
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Sichuan Province