WGCNA combined with machine learning to explore potential biomarkers and treatment strategies for acute liver failure, with experimental validation
We identified <i>HORMAD2</i>, <i>WNT10A</i>, <i>ATP6V1E2</i>, <i>CMBL</i>, <i>ARRDC4</i>, and <i>LPIN2</i>, as diagnostic biomarkers for ALF and demonstrated the effectiveness of eriodictyol for treating ALF. Immune cell infiltration may play a significant role in the pathogenesis and progression of ALF.
Authors
- Xiaomei Zheng (ORCID: https://orcid.org/0000-0002-9916-9601)
- Gang Ye (ORCID: https://orcid.org/0000-0001-7382-3938)
- Xinyan Wu (ORCID: https://orcid.org/0000-0002-2836-0804)
Institutions
- Sichuan Agricultural University (CN)
Publication Details
- Journal
- iLiver
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1016/j.iliver.2024.100133
- Citations
- 9
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 3.33
Funders
- Sichuan University