Unveiling significance of peripheral nervous system glia: implications for nervous system disorders and therapeutic interventions

Glial cells are indispensable components of the peripheral nervous system (PNS), exerting diverse regulatory functions crucial for neuronal health and function. From myelination and synaptic modulation to immune regulation, glia actively participate in maintaining PNS homeostasis and responding to pathological insults. Further elucidating the roles of glial cells in peripheral nerve disorders holds promise for developing targeted therapeutic interventions to alleviate symptoms and improve patient outcomes. The aim of this article was to review the multifaceted functions of PNS glia in shaping nervous system function and their intricate involvement in various neuropathologies, including peripheral neuropathies, neuroinflammatory conditions, and gastrointestinal disorders. Understanding the underlying mechanisms of glial dysfunction offers opportunities for developing targeted therapeutic interventions aimed at preserving nerve function, attenuating neuroinflammation, and restoring gastrointestinal homeostasis. Growing research on PNS glia underlines their indispensable role and highlights the potential of therapeutic strategies targeting glial dysfunction in revolutionising the management of nervous system disorders, offering hope for improved patient outcomes and quality of life.