Synaptic Density in Early Stages of Psychosis and Clinical High Risk
This study found that synaptic density reductions were present during the early stages of psychosis and its risk states and associated with negative symptoms. The implications of SV2A for negative symptoms in psychosis and CHR warrant further investigation. Future studies should investigate the impact of cannabis use on synaptic density in CHR longitudinally.
Authors
- Romina Mizrahi (ORCID: https://orcid.org/0000-0001-6667-7928)
- Christine Tardif (ORCID: https://orcid.org/0000-0001-8356-6808)
- Pablo Rusjan (ORCID: https://orcid.org/0000-0003-0075-2918)
- J. Pinto Cohen (ORCID: https://orcid.org/0000-0002-1319-9827)
- Ilana R. Leppert (ORCID: https://orcid.org/0000-0001-7672-0918)
- M. Belen Blasco (ORCID: https://orcid.org/0009-0000-2456-9101)
- Christian Ramos-Jiménez (ORCID: https://orcid.org/0000-0003-1637-6179)
- Kankana Nisha Aji
Institutions
- Montreal Neurological Institute and Hospital (CA)
- Douglas College (CA)
- Douglas Mental Health University Institute (CA)
- McGill University (CA)
Publication Details
- Journal
- JAMA Psychiatry
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1001/jamapsychiatry.2024.3608
- Citations
- 13
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 5.26