Population-Level Frequency of Fluoroquinolone Resistance by Whole-Genome Sequencing Drug Predictions in <i>Mycobacterium tuberculosis</i> Complex Isolates in England From 2017 Through 2023
Fluoroquinolones are increasingly important for anti-tuberculosis (TB) treatment. Identifying fluoroquinolone resistance (FR) is essential. Using sequencing data from over 16 000 unselected isolates, this first English survey of FR, found it present in 1.4% overall and 23.9% of multidrug-resistant TB. Routine sequencing allows clinically-relevant resistance surveillance and should be widely adopted.
Authors
- Cathleen Chan
- Eliza Alexander (ORCID: https://orcid.org/0000-0002-7043-1725)
- Noorann Sheikh
- Esther Robinson (ORCID: https://orcid.org/0009-0003-0913-3627)
- Martin Dedicoat (ORCID: https://orcid.org/0000-0001-9833-4882)
- Ana Lúıza Gibertoni Cruz (ORCID: https://orcid.org/0000-0002-9473-2215)
- Marc Lipman (ORCID: https://orcid.org/0000-0001-7501-4448)
- Elena Ferran (ORCID: https://orcid.org/0000-0002-8472-7383)
- James Brown (ORCID: https://orcid.org/0000-0002-2820-5847)
Institutions
- University Hospitals Birmingham NHS Foundation Trust (GB)
- Royal Free London NHS Foundation Trust (GB)
- The London College (GB)
- UK Health Security Agency (GB)
- University College London (GB)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1093/cid/ciae560
- Citations
- 4
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.56