The co-expression of the depolarizing and hyperpolarizing mechanosensitive ion channels in mammalian retinal neurons
Individual neurons co-express hyperpolarizing K-MSCs with depolarizing N-MSCs to counterbalance the pressure-induced excitation, and the level of K-MSCs relative to N-MSCs (<i>R<sub>K/N</sub></i> ratio) is balanced in the outer retina but low in RGCs, bringing out novel determinants for the pressure vulnerability of retinal neurons and new targets for clinical interventions.
Authors
- Zhuo Yang (ORCID: https://orcid.org/0000-0001-5212-0053)
- Junxiong Pang (ORCID: https://orcid.org/0000-0002-9788-701X)
- Ji‐Jie Pang
- Samuel M. Wu
Institutions
- Baylor College of Medicine (US)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2024-11-13
- DOI
- https://doi.org/10.3389/fmed.2024.1463898
- Citations
- 1
- Primary Topic
- Connexins and lens biology
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- Research to Prevent Blindness
- Retina Research Foundation
- National Institutes of Health