CircBTBD7-420aa Regulates the Progression of Atherosclerosis
Circular RNAs are associated with cardiovascular disease, including coronary artery disease, but the mechanisms have not been completely elucidated. We found a new protein, circBTBD7-420aa, encoded by hsa_circ_0000563. Our results suggest that circBTBD7-420aa may inhibit the abnormal proliferation and migration of human coronary artery smooth muscle cells by promoting SLC3A2 degradation through the ubiquitin-proteasome pathway. In addition, we constructed engineered exosomes loaded with circBTBD7-420aa that can target vascular smooth muscle cells by modifying peptide fragments targeting osteopontin. This study suggests that circBTBD7-420aa may inhibit the progression of atherosclerosis and serve as a new target for the diagnosis and treatment of coronary artery disease.
Authors
- Boyu Chi (ORCID: https://orcid.org/0000-0003-3147-9934)
- Qiaowei Jia
- En‐Zhi Jia (ORCID: https://orcid.org/0000-0003-1354-9855)
- Qiangba Yangzong
- Zhenyu Zhao
- Ren‐You Pan (ORCID: https://orcid.org/0000-0002-4814-2978)
- Xiongkang Gan (ORCID: https://orcid.org/0000-0002-8245-6073)
- Weixin Sun
- Yahong Fu (ORCID: https://orcid.org/0000-0002-4577-032X)
- Chengcheng Li (ORCID: https://orcid.org/0000-0002-4843-5404)
- Yanjun Wang (ORCID: https://orcid.org/0000-0001-7825-4332)
- Sheng Zhang (ORCID: https://orcid.org/0000-0001-8206-1007)
- Mengmeng Ren
- Shu He (ORCID: https://orcid.org/0000-0001-7914-5779)
- Xiumei Chen (ORCID: https://orcid.org/0000-0002-4174-1230)
- Hanxiao Zhou (ORCID: https://orcid.org/0000-0002-2052-0076)
- Yu‐Li Chen (ORCID: https://orcid.org/0000-0002-9742-4752)
- Hengjie Bie
- Ciren Zhongga
- Xin Zhang (ORCID: https://orcid.org/0000-0003-0047-3134)
- Qian Zhang (ORCID: https://orcid.org/0000-0001-5975-9781)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Suzhou Municipal Hospital (CN)
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- JACC Basic to Translational Science
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1016/j.jacbts.2024.09.003
- Citations
- 2
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Tibet Autonomous Region