Modified poly-L-lysine for use as a clearing agent in pretargeted radioimmunotherapy
The straightforward synthesis of poly-L-lysine based clearing agents makes kit preparation possible and these agents show good potential for further evaluation, especially within the Tetrazine/Transcyclooctene pretargeting system where no liver or kidney accumulation was observed.
Authors
- Damian J. Green (ORCID: https://orcid.org/0000-0003-0477-1446)
- Chiara Timperanza (ORCID: https://orcid.org/0000-0003-4914-0023)
- Anna Gustafsson-Lutz
- Emma Aneheim (ORCID: https://orcid.org/0000-0003-2566-886X)
- Tom Bäck (ORCID: https://orcid.org/0000-0002-3375-9473)
- Sture Lindegren (ORCID: https://orcid.org/0000-0003-4288-0467)
Institutions
- University of Washington (US)
- Sahlgrenska University Hospital (SE)
- Fred Hutch Cancer Center (US)
- University of Gothenburg (SE)
Publication Details
- Journal
- EJNMMI Radiopharmacy and Chemistry
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1186/s41181-024-00307-6
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cancerfonden
- Göteborgs Universitet
- Stiftelsen Jubileumsklinikens Forskningsfond mot Cancer