<i>APEX1</i> Polymorphisms Affect Acute Myeloid Leukemia Risk, and Its Expression Is Involved in Cell Proliferation and Differentiation
In the GSE48558 dataset, AML cells and normal CD34+ cells expressed APEX1 at higher levels than did granulocytes (p < 0.01). Functional experiments revealed that APEX1 knockdown led to a reduction in AML cell proliferation. These findings indicated that APEX1 polymorphisms were a potential risk factor for AML and highlighted the important role of APEX1 in regulating AML cell differentiation and proliferation.
Authors
- Minako Iida
- Tsukasa Oda (ORCID: https://orcid.org/0000-0002-8941-161X)
- Tetsuhiro Kasamatsu (ORCID: https://orcid.org/0000-0002-7943-9176)
- Natsuki Shiraishi
- Hirokazu Murakami (ORCID: https://orcid.org/0000-0003-1766-4615)
- Akiko Omori (ORCID: https://orcid.org/0009-0002-9279-6917)
- Nanami Gotoh (ORCID: https://orcid.org/0000-0002-2381-319X)
- Ikuko Matsumura
- Nobuo Sasaki (ORCID: https://orcid.org/0000-0002-8798-7244)
- Yuki Itoi
- Hiroshi Handa (ORCID: https://orcid.org/0000-0003-3753-9862)
- Akihiko Yokohama (ORCID: https://orcid.org/0000-0001-8514-086X)
- Takayuki Saitoh (ORCID: https://orcid.org/0000-0001-5524-7455)
- Yuya Kitamura
- Eiji Miyauchi (ORCID: https://orcid.org/0000-0002-8202-684X)
- H. Negishi
- Kota Yanagisawa
- Satoru Takada
- Runa Aoyagi
Institutions
- Gunma University (JP)
- Gunma Saiseikai Maebashi Hospital (JP)
- Gunma University of Health and Welfare (JP)
- Gunma University Hospital (JP)
Publication Details
- Journal
- International Journal of Laboratory Hematology
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1111/ijlh.14401
- Citations
- 1
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.45
Funders
- Japan Society for the Promotion of Science
- Institute for Molecular and Cellular Regulation, Gunma University