Glioblastoma cells alter brain endothelial cell homeostasis and tight junction protein expression in vitro
The current findings suggest that U87 cells alter the integrity of bEnd.3 cells possibly through the secretomes in the CM and through cell-cell interactions in co-culture models. This may assist in the understanding of the mechanisms by which GBM affects the BBB, which may aid in the management thereof.
Authors
- Werner Cordier (ORCID: https://orcid.org/0000-0002-5744-9285)
- Brian Thabile Flepisi (ORCID: https://orcid.org/0000-0002-0628-4636)
- Peace Mabeta
- Xolisile Mokoena
Institutions
- University of Pretoria (ZA)
Publication Details
- Journal
- Journal of Neuro-Oncology
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1007/s11060-024-04870-5
- Citations
- 2
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.49
Funders
- South African Medical Research Council
- University of Pretoria
- Medical Research Council