Exosomes derived from IFNγ-stimulated mesenchymal stem cells protect photoreceptors in RCS rats by restoring immune homeostasis through tsRNAs
IFNγ stimulation enhanced the neuroprotective effects of MSC-derived exosomes on photoreceptors of the degenerative retina, which may be mediated by immune regulatory tsRNAs acting on microglia. In conclusion, IFNγ-Exo is a promising nanotherapeutic agent for the treatment of retinitis pigmentosa.
Authors
- A Luodan
- Qingle Liang (ORCID: https://orcid.org/0009-0008-5975-2078)
- Linghui Qu
- Haiwei Xu (ORCID: https://orcid.org/0000-0002-8840-7918)
- Juncai He (ORCID: https://orcid.org/0000-0003-0088-833X)
- Hong Gong (ORCID: https://orcid.org/0000-0003-4393-1078)
- Siyu Chen (ORCID: https://orcid.org/0009-0002-1503-9402)
- Jing Xie (ORCID: https://orcid.org/0000-0002-9099-8315)
- Xiaona Huang (ORCID: https://orcid.org/0000-0002-8008-6507)
- Hui Gao (ORCID: https://orcid.org/0009-0007-8695-6159)
- Lingling Ge (ORCID: https://orcid.org/0000-0002-1797-3752)
- Tianjing You
Institutions
- Army Medical University (CN)
- Xinqiao Hospital (CN)
- Southwest Hospital (CN)
- 458th Hospital PLA (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1186/s12964-024-01920-3
- Citations
- 12
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- National Natural Science Foundation of China