Declining genetic polymorphism of the C-terminus Merozoite Surface Protein-1 amidst increased Plasmodium knowlesi transmission in Thailand
This study highlights a decline in genetic diversity and evidence of purifying selection associated with the recently increased incidence of P. knowlesi malaria in Thailand. The minor genetic differentiation between P. knowlesi populations from southern Thailand and Malaysia suggests a shared recent ancestry of these parasites and underscores the need for coordinated efforts between the two countries for the elimination of P. knowlesi.
Authors
- Liwang Cui (ORCID: https://orcid.org/0000-0002-8338-1974)
- Parsakorn Tapaopong (ORCID: https://orcid.org/0009-0002-6461-9948)
- Jetsumon Sattabongkot (ORCID: https://orcid.org/0000-0002-3938-4588)
- Wang Nguitragool (ORCID: https://orcid.org/0000-0002-5484-7130)
- Wanlapa Roobsoong (ORCID: https://orcid.org/0000-0002-1789-0439)
- Sittinont Chainarin
- Teera Kusolsuk (ORCID: https://orcid.org/0000-0003-1933-8493)
- Sirasate Bantuchai (ORCID: https://orcid.org/0000-0003-3093-2485)
- Nikom Kangkasikorn
- Abdulrohman Mala
- Arnuwat Rannarong
Institutions
- Mahidol University (TH)
- University of South Florida (US)
- Mahidol Oxford Tropical Medicine Research Unit (TH)
Publication Details
- Journal
- Malaria Journal
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1186/s12936-024-05162-z
- Citations
- 2
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 1.09
Funders
- Mahidol University