Modeling ventilation of patients with interstitial lung disease at rest and exercise: a bench study
In this bench study, we personalized a mechanical simulator thatmodels the lung inhomogeneity and spontaneous breathing of healthy subjects and ILD patients at rest and during exercise. Our results suggest that lung inhomogeneity could increase lung vulnerability to volo-atelec-trauma mechanisms in ILD. Further physiological studies are needed to evaluate the impact of this vulnerability on acute or chronic ILD worsening.
Authors
- Tristan Bonnevie (ORCID: https://orcid.org/0000-0003-0550-813X)
- Christophe Girault (ORCID: https://orcid.org/0000-0002-7794-3707)
- Francis‐Edouard Gravier (ORCID: https://orcid.org/0000-0003-3518-2898)
- David Debeaumont
- Clémence Roussel
- Emeline Fresnel (ORCID: https://orcid.org/0000-0002-3011-7694)
- Marie-Anne Mélone (ORCID: https://orcid.org/0000-0002-3407-7351)
- Élise Artaud-Macari (ORCID: https://orcid.org/0000-0001-7604-6839)
- Adrien Kerfourn (ORCID: https://orcid.org/0000-0002-8835-2304)
- Mathieu Salaün (ORCID: https://orcid.org/0000-0003-1430-6396)
- Antoine Cuvelier
Institutions
- Laboratoire d'Informatique, du Traitement de l'Information et des Systèmes (FR)
- ADIR Association (FR)
- Institute for Research and Innovation in Biomedicine (FR)
- Centre Hospitalier Universitaire de Rouen (FR)
- Université de Rouen Normandie (FR)
Publication Details
- Journal
- BMC Pulmonary Medicine
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1186/s12890-024-03383-1
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00