Low-frequency variants in genes involved in glutamic acid metabolism and γ-glutamyl cycle and risk of coronary artery disease in type 2 diabetes
In summary, we have identified low-frequency variants associated with CAD in T2D at two loci involved in glutamic acid metabolism and the γ-glutamyl cycle. These findings provide further evidence for a role of these pathways in the link between T2D and CAD.
Authors
- Alessandro Doria (ORCID: https://orcid.org/0000-0002-3830-4304)
- Fernando M. A. Giuffrida (ORCID: https://orcid.org/0000-0002-5566-8070)
- Hetal Shah (ORCID: https://orcid.org/0000-0002-3685-4572)
- Marcus G. Pezzolesi (ORCID: https://orcid.org/0000-0002-4093-3783)
- Qi Sun (ORCID: https://orcid.org/0000-0002-8480-1563)
- Scott G. Frodsham
- Kunal Sharan (ORCID: https://orcid.org/0000-0003-2139-2544)
- Yaling Tang (ORCID: https://orcid.org/0000-0002-2405-2855)
- Christine Mendonça
Institutions
- Brigham and Women's Hospital (US)
- Joslin Diabetes Center (US)
- Harvard University (US)
- University of Utah (US)
- Universidade Salvador (BR)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1186/s12933-024-02442-5
- Citations
- 3
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- National Institutes of Health
- Canadian Institutes of Health Research