Follicular fluid-derived extracellular vesicles miR-34a-5p regulates granulosa cell glycolysis in polycystic ovary syndrome by targeting LDHA
The findings of this study show that miR-34a-5p mediates GC apoptosis in PCOS by targeting LDHA and inhibiting glycolysis, suggesting its crucial role in PCOS pathophysiology, and offering potential therapeutic targets for improving follicular development and fertility outcomes in patients with PCOS. Further research is needed to explore the clinical implications of miR-34a-5p and its use as a biomarker for early diagnosis and prognosis of PCOS.
Authors
- Tao Huang (ORCID: https://orcid.org/0000-0002-7086-570X)
- Xiaocan Lei (ORCID: https://orcid.org/0000-0001-7666-5082)
- Wanting Peng
- Zhiwei Shen (ORCID: https://orcid.org/0009-0003-8348-8303)
- Shun Zhang (ORCID: https://orcid.org/0000-0002-3804-7475)
- Jingjing Yu (ORCID: https://orcid.org/0000-0002-2408-5809)
- Xueying Cui
- Xiuli Yang
- Xueyan Mao
- Peng Huo
Institutions
- Guilin Medical University (CN)
- University of South China (CN)
Publication Details
- Journal
- Journal of Ovarian Research
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1186/s13048-024-01542-w
- Citations
- 18
- Primary Topic
- Ovarian function and disorders
- Type
- article
- Field-Weighted Citation Impact
- 9.67
Funders
- National Natural Science Foundation of China
- Guangxi University