Development and characterization of gastro-floating sustained-release granules for enhanced bioavailability of patchouli oil
The oil-laden granules were prepared using colloidal silicon dioxide (CSD) for oil adsorption and to provide buoyancy, along with ethyl cellulose (EC) and hydroxypropyl methyl cellulose (HPMC) to form a sustained-release matrix. The CSD exhibited favorable characteristics for oil adsorption and floating. Compatibility between PO and CSD was affirmed through DSC thermograms and FTIR spectra. The obtained granules demonstrated a sustained release profile, achieving over 90 % release within 10 h without an initial burst. After oral administration, the granules were observed to remain in the gastric region of rats for over 7 h. The bioavailability of patchouli alcohol from the optimized granules was significantly higher than that from of the PO-loaded powders. The gastro-floating sustained-release granules, based on a CSD/EC/HPMC matrix, offer a simple yet effective strategy to improve the delivery efficacy of PO against <i>Helicobacter pylori</i> infections in the gastric region.
Authors
- Wenping Wang (ORCID: https://orcid.org/0009-0009-6115-3880)
- Yanni Ma
- Boli Li (ORCID: https://orcid.org/0000-0002-6599-6959)
- Jiao Wang (ORCID: https://orcid.org/0000-0003-2959-8280)
- Ye Zou (ORCID: https://orcid.org/0000-0002-2320-786X)
- Yanan Wu (ORCID: https://orcid.org/0000-0002-0494-6739)
- Xia Zhang (ORCID: https://orcid.org/0000-0003-2740-5190)
- Chen Liu (ORCID: https://orcid.org/0000-0002-0180-7178)
Institutions
- Ningxia Medical University (CN)
- Yunnan University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e40374
- Citations
- 1
- Primary Topic
- Food Chemistry and Fat Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.35
Funders
- National Natural Science Foundation of China