FTO suppresses cardiac fibrosis after myocardial infarction via m6A-mediated epigenetic modification of EPRS
FTO, identified as a cardioprotective factor, suppressed collagen synthesis in post-infarction cardiac fibrosis via m<sup>6</sup>A modification, which provided a new therapeutic strategy for cardiac fibrosis.
Authors
- Yafang Zha
- Yanyan Li (ORCID: https://orcid.org/0000-0002-2939-9065)
- Jian Wang (ORCID: https://orcid.org/0000-0003-3391-5250)
- Song Zhang (ORCID: https://orcid.org/0000-0003-0067-5780)
- Lijie Deng
Institutions
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- XinHua Hospital (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1186/s10020-024-00985-7
- Citations
- 8
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China
- Shanghai Jiao Tong University
- Renji Hospital
- School of Medicine, Shanghai Jiao Tong University