Methionine restriction promotes the polarization of macrophages towards M1 and the immunotherapy effect of PD-L1/PD-1 blockades by inhibiting the secretion of MIF by gastric carcinoma cells
MR inhibits the secretion of MIF by gastric carcinoma cells, promotes macrophage M1 polarization, and enhances the therapeutic effect of PD-L1/PD-1 blockades in gastric cancer.
Authors
- Jin‐Heng Gan
- J L Laï (ORCID: https://orcid.org/0000-0002-2355-3156)
- Zhen Yue (ORCID: https://orcid.org/0000-0001-6993-6067)
- Yonghui Zou (ORCID: https://orcid.org/0000-0002-9891-2977)
- Luo‐Jun Fan
- Qi Zhou (ORCID: https://orcid.org/0000-0002-0441-584X)
- Jiang Liu (ORCID: https://orcid.org/0000-0002-5755-3904)
- Xin Lin (ORCID: https://orcid.org/0000-0002-0594-6319)
- He‐Song Xu
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Second Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Translational Oncology
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1016/j.tranon.2024.102181
- Citations
- 6
- Primary Topic
- Macrophage Migration Inhibitory Factor
- Type
- article
- Field-Weighted Citation Impact
- 1.44
Funders
- National Natural Science Foundation of China