The Role of Delta-Opioid Receptor in Mediating the Cardioprotective Effects of Morphine Preconditioning via the JAK2/STAT3 Pathway in a Failing Heart
DOR protein levels increased in failing hearts of both humans and rats. Blocking cardiac DOR selectively reduced morphine-induced cardio protection by inhibiting the JAK2/STAT3 pathway. These findings indicate that cardiac DOR is a potential therapeutic target for protecting against heart failure due to I/R injury.
Authors
- Shiyun Jin (ORCID: https://orcid.org/0000-0003-2610-3318)
- Shufang He (ORCID: https://orcid.org/0000-0001-9896-5705)
- Juan Wu (ORCID: https://orcid.org/0000-0002-2580-9936)
- Xinxin Pan
- Chengxiao Guo
- Ye Zhang (ORCID: https://orcid.org/0000-0002-0627-7057)
- Baoli Wang
- Bingzhang Cao
- Xinyu Chen (ORCID: https://orcid.org/0000-0002-6769-3046)
Institutions
- Anhui Medical University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Anesthesia & Analgesia
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1213/ane.0000000000007290
- Citations
- 5
- Primary Topic
- Cardiac Ischemia and Reperfusion
- Type
- article
- Field-Weighted Citation Impact
- 2.12