Evaluating the Causal Association between Circulating Plasma Proteins, 731 Immune Cell Phenotypes, and Atopic Dermatitis: A Mediation Mendelian Randomization Study
Our findings indicated the presence of a one-way causal relationship between the circulating plasma protein IFNA16 and AD. This study also explored immune cell phenotypes that may serve as mediators, offering novel insights into the etiology, pathogenesis, and potential clinical interventions in AD. Nevertheless, these findings need to be validated by clinical and laboratory studies.
Authors
- Kuan Lai (ORCID: https://orcid.org/0000-0002-3957-3709)
- Junhao Zhu (ORCID: https://orcid.org/0000-0002-3301-5677)
- Silang Zhu
- Qian Li (ORCID: https://orcid.org/0000-0002-7911-9172)
- Shan Yang (ORCID: https://orcid.org/0000-0002-8249-0183)
- Wenjing Zhang (ORCID: https://orcid.org/0000-0002-7812-6274)
- Shanshan Wei (ORCID: https://orcid.org/0000-0003-4185-0346)
- Yin Li (ORCID: https://orcid.org/0000-0002-4019-3391)
Institutions
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Nanfang Hospital (CN)
- Zhujiang Hospital (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- International Archives of Allergy and Immunology
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1159/000542527
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00