“Silent” HPV-associated cervical cancer – isolated cerebellar metastasis as unusual sign of cervical adenocarcinoma: a case report and literature review

Background.This report focuses on an unusual case of primary central nervous system metastasis (CNS) from gynaecological cancer, specifically endocervical carcinoma, which typically occurs as part of a disseminated disease.Brain metastases from cervical cancer are rare, occurring in only 2% of cases.We reported data from hospital registry and the available literature with using the PRISMA methodology.Case presentation.The patient, a 48-year-old woman without relevant medical history or gynaecological symptoms, went to the Emergency Room with progressive neurological symptoms.Imaging revealed obstructive hydrocephalus due to a mass in the IV ventricle, later identified as a cerebellar metastasis.Despite negative routine cervical screening, subsequent examinations revealed advanced cervical cancer with aggressive histology.The patient's poor performance status precluded standard treatments, so she underwent palliative care.Unfortunately, she succumbed to the disease after eight months.Isolated cerebellar metastasis as unusual first sign of HPV-associated cervical cancer Marco Cerbone, Anna Aquilino, Maria Bardi, et al.Isolated cerebellar metastasis as unusual first sign of HPV-associated cervical cancer Marco Cerbone, Anna Aquilino, Maria Bardi, et al.Isolated cerebellar metastasis as unusual first sign of HPV-associated cervical cancer