In vitro antifungal activities of medicinal plants used for treatment of candidiasis in Pader district, Northern Uganda

Methanol extract of K. anthotheca, aqueous extract (24.4 °C) of M. rubrostipulata, and combination of aqueous extract (60 °C) of D. dissectus + methanol extract of K. anthotheca could be effective in the treatment of candidiasis. They demonstrated potential broad spectrum antifungal activity against different species and strains of tested Candida than the fluconazole and amphotericin B drugs. Their fungistatic nature showed their ability to inhibit fungal growth. Hence, these extracts/extract combination can offer better treatment option for candidiasis if they are standardized and also their active curative compounds isolated and made into antifungal drugs.

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Publication Details

Journal
Tropical Medicine and Health
Published
2024-11-13
DOI
https://doi.org/10.1186/s41182-024-00628-x
Citations
5
Primary Topic
Antifungal resistance and susceptibility
Type
article
Field-Weighted Citation Impact
1.95

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article

In vitro antifungal activities of medicinal plants used for treatment of candidiasis in Pader district, Northern Uganda

Savina Asiimwe, Betty Akwongo, Esezah Kakudidi, Mary Namaganda et al.
5 citations
Tropical Medicine and Health
Antifungal resistance and susceptibility
1.95
article

In vitro antifungal activities of medicinal plants used for treatment of candidiasis in Pader district, Northern Uganda

Savina Asiimwe, Betty Akwongo, Esezah Kakudidi, Mary Namaganda, Godwin Anywar, Esther Katuura, Patience Tugume, Anthony M. Nsubuga, Morgan Andama
article en
5 citations

Abstract

Methanol extract of K. anthotheca, aqueous extract (24.4 °C) of M. rubrostipulata, and combination of aqueous extract (60 °C) of D. dissectus + methanol extract of K. anthotheca could be effective in the treatment of candidiasis. They demonstrated potential broad spectrum antifungal activity against different species and strains of tested Candida than the fluconazole and amphotericin B drugs. Their fungistatic nature showed their ability to inhibit fungal growth. Hence, these extracts/extract combination can offer better treatment option for candidiasis if they are standardized and also their active curative compounds isolated and made into antifungal drugs.

Tropical Medicine and HealthVol. 52(1)
Muni University (UG), Makerere University (UG)
Mbarara University of Science and Technology
Clean water and sanitation
Openalex Percentile: Top 13%
Antifungal resistance and susceptibility
1.95
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