In vitro antifungal activities of medicinal plants used for treatment of candidiasis in Pader district, Northern Uganda
Methanol extract of K. anthotheca, aqueous extract (24.4 °C) of M. rubrostipulata, and combination of aqueous extract (60 °C) of D. dissectus + methanol extract of K. anthotheca could be effective in the treatment of candidiasis. They demonstrated potential broad spectrum antifungal activity against different species and strains of tested Candida than the fluconazole and amphotericin B drugs. Their fungistatic nature showed their ability to inhibit fungal growth. Hence, these extracts/extract combination can offer better treatment option for candidiasis if they are standardized and also their active curative compounds isolated and made into antifungal drugs.
Authors
- Savina Asiimwe
- Betty Akwongo (ORCID: https://orcid.org/0000-0002-7855-2935)
- Esezah Kakudidi (ORCID: https://orcid.org/0000-0003-3808-4126)
- Mary Namaganda (ORCID: https://orcid.org/0000-0002-1665-8929)
- Godwin Anywar (ORCID: https://orcid.org/0000-0003-0926-1832)
- Esther Katuura (ORCID: https://orcid.org/0000-0002-1780-4596)
- Patience Tugume (ORCID: https://orcid.org/0000-0002-2965-6500)
- Anthony M. Nsubuga
- Morgan Andama
Institutions
- Muni University (UG)
- Makerere University (UG)
Publication Details
- Journal
- Tropical Medicine and Health
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1186/s41182-024-00628-x
- Citations
- 5
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 1.95
Funders
- Mbarara University of Science and Technology