Determination of selected oxysterol levels, oxidative stress, and macrophage activation indicators in children and adolescents with familial hypercholesterolemia
This study highlights the key roles of oxysterols, oxidative stress, and macrophage activation in the development of atherosclerosis in pediatric and adolescent patients with FH. Elevated C-Triol levels in FH patients, alongside increased CIMT, point to early vascular changes despite atorvastatin therapy. In contrast, higher 27-OHC levels in healthy controls suggest differential oxysterol regulation due to cholesterol-lowering treatments in FH patients. C-Triol and 27-OHC/Total-C ratios showed potential as biomarkers to distinguish patients with FH. These findings emphasize the need for therapies targeting oxidative stress and macrophage activation in addition to cholesterol-lowering interventions.
Authors
- Ertürk Levent (ORCID: https://orcid.org/0000-0002-7878-7531)
- Derya Aydın
- Ebru Sezer (ORCID: https://orcid.org/0000-0002-6900-3539)
- Mahmut Çöker (ORCID: https://orcid.org/0000-0002-6308-6804)
- Dilek Düzgün
- Havva Yazıcı (ORCID: https://orcid.org/0000-0002-2564-7420)
- Sema Kalkan Uçar (ORCID: https://orcid.org/0000-0001-9574-7841)
- Eser Yıldırım Sözmen (ORCID: https://orcid.org/0000-0002-6383-6724)
- Erhan Canbay (ORCID: https://orcid.org/0000-0003-0948-1675)
- Ebru Canda (ORCID: https://orcid.org/0000-0002-9175-1998)
- Öznur Çopur (ORCID: https://orcid.org/0000-0003-2418-7626)
- Burak Durmaz (ORCID: https://orcid.org/0000-0002-5285-3641)
- Gulcin Kayan Kasıkcı
- Begüm Tahhan
- Zeynep Elçim Koru
Institutions
- Izmir University (TR)
- Ege University (TR)
- Lokman Hekim Üniversitesi (TR)
- Near East University (CY)
Publication Details
- Journal
- Lipids in Health and Disease
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1186/s12944-024-02371-y
- Citations
- 4
- Primary Topic
- Cholesterol and Lipid Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.29
Funders
- Türkiye Bilimsel ve Teknolojik Araştırma Kurumu