Loop33 × 123 CAR-T targeting CD33 and CD123 against immune escape in acute myeloid leukemia
Loop33 × 123 CAR-T targeting CD33 and CD123 could efficiently eliminate AML cells and prolong survival of tumor-bearing mice, while addressing the issue of immune escape.
Authors
- Tian Zheng (ORCID: https://orcid.org/0000-0003-4889-0391)
- Shaowei Qiu (ORCID: https://orcid.org/0000-0003-3866-0066)
- Yingxi Xu (ORCID: https://orcid.org/0000-0002-0056-7440)
- Qing Rao (ORCID: https://orcid.org/0000-0001-6721-1337)
- Jianxiang Wang (ORCID: https://orcid.org/0000-0001-9437-9151)
- Haiyan Xing
- Min Wang (ORCID: https://orcid.org/0000-0003-1637-0324)
- Zhifeng Yan (ORCID: https://orcid.org/0000-0002-6930-3128)
- Runxia Gu (ORCID: https://orcid.org/0000-0001-8607-207X)
- Haotian Ma (ORCID: https://orcid.org/0000-0003-2114-5586)
- Kejing Tang (ORCID: https://orcid.org/0000-0002-5454-4666)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Tianjin Conservatory of Music (CN)
- Tianjin Anding Hospital (CN)
- Institute of Hematology & Blood Diseases Hospital (CN)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1007/s00262-024-03847-7
- Citations
- 7
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 1.98
Funders
- National Natural Science Foundation of China