Serum growth differentiation factor-15, glial fibrillary acidic protein, and neurofilament light chain: Their link and role in Creutzfeldt-Jakob disease
In conclusion, this study explores the potential of sNfL, sGDF-15, and sGFAP as biomarkers in CJD patients. The higher levels of sNfL and sGFAP in CJD patients compared to healthy controls, along with the observed sex differences in sGFAP, highlight the need for further research into the interaction between astroglia and neurons in CJD, with a focus on sex as a key variable.
Authors
- Domenico Plantone (ORCID: https://orcid.org/0000-0001-6666-7244)
- Nicola De Stefano (ORCID: https://orcid.org/0000-0003-4930-7639)
- Carlo Manco (ORCID: https://orcid.org/0000-0003-4572-2616)
- Sara Locci
- Sabina Bartalini
- Delia Righi (ORCID: https://orcid.org/0009-0001-3352-5618)
- Roberto Marconi
Institutions
- University of Siena (IT)
- Ospedale Misericordia - Grosseto (IT)
Publication Details
- Journal
- Journal of the Neurological Sciences
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1016/j.jns.2024.123305
- Citations
- 2
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Regione Toscana