Iron-catalyzed ligand-free diazidation of alkenes controlled by the ratio of TBHP to TMSN <sub>3</sub>
The diazidation of alkenes through an iron-catalyzed, ligand-free system has been established, providing straightforward access to structurally vicinal diazides in good yields at room temperature with TMSN<sub>3</sub> as the azido source. The ratio of <sup><i>t</i></sup>BuOOH to TMSN<sub>3</sub> was essential for the reaction: one equivalent TMSN<sub>3</sub> was needed to react with <sup><i>t</i></sup>BuOOH to form HN<sub>3</sub> as a nucleophile in the reaction ultimately achieving the diazidation of alkenes.
Authors
- G. ZHANG
- Xinyue Li (ORCID: https://orcid.org/0009-0005-4058-6733)
- Min Jiang (ORCID: https://orcid.org/0000-0001-7703-9753)
- Xingyu Li (ORCID: https://orcid.org/0000-0002-2946-5448)
- Fang Fang (ORCID: https://orcid.org/0009-0008-0981-8366)
- Shu Tang
- Qian He (ORCID: https://orcid.org/0000-0003-3744-8805)
- Hongzhou Yu
Institutions
- Anhui University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1039/d4ob01698j
- Citations
- 1
- Primary Topic
- Synthesis and Catalytic Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.25
Funders
- Anhui University of Chinese Medicine