A global lipid map of severe fever with thrombocytopenia syndrome virus infection reveals glycerophospholipids as novel prognosis biomarkers
This study systematically investigated the lipid landscape profile of SFTS-infected patients with different clinical outcomes. Our results revealed a global alteration in the lipid signature, particularly the glycerophospholipid metabolic pathway, induced by SFTSV infection. Notably, LysoPC (20:0) and LysoPC (P-16:0) presented remarkable prognostic value as novel biomarkers for SFTSV infection and may contribute to the prognosis of SFTS progression and appropriate interventions.
Authors
- Wanying Zhang (ORCID: https://orcid.org/0000-0002-6066-3493)
- Guiting Zhang
- Yuxin Chen (ORCID: https://orcid.org/0000-0001-5955-687X)
- Mingrong Ou
- Panpan Tian (ORCID: https://orcid.org/0000-0002-1356-7140)
- Yidan Sun (ORCID: https://orcid.org/0000-0001-8238-8026)
- Shixing Chen (ORCID: https://orcid.org/0000-0002-8768-8156)
- Liwei Zhao
Institutions
- Nanjing University of Chinese Medicine (CN)
- Nanjing Drum Tower Hospital (CN)
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- mBio
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1128/mbio.02628-24
- Citations
- 5
- Primary Topic
- Viral Infections and Vectors
- Type
- article
- Field-Weighted Citation Impact
- 1.95
Funders
- Jiangsu Commission of Health
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Nanjing Medical University