Optimization of in vivo antimalarial efficacy of combinations of aqueous leaf extracts of Artemisia annua L., Vernonia amygdalina Del, and Microglossa pyrifolia (Lam.) Kuntze using factorial design
An optimum combination of the three plants as a natural herbal antimalarial therapy was obtained using factorial design, and it offers an alternative to first line Artemisinin based Combination Therapy (ACTs) as parasite resistance looms. This combination could be further developed into a standard phytopharmaceutical and subjected to Randomized Controlled Trials (RCTs).
Authors
- Jimmy Ronald Angupale (ORCID: https://orcid.org/0009-0009-5891-7587)
- Jonans Tusiimire (ORCID: https://orcid.org/0000-0002-5831-1499)
- Ndidi C. Ngwuluka (ORCID: https://orcid.org/0000-0003-4028-2228)
- Clement Olusoji Ajayi (ORCID: https://orcid.org/0000-0003-4208-1489)
Institutions
- Mbarara University of Science and Technology (UG)
- University of Jos (NG)
Publication Details
- Journal
- BMC Complementary Medicine and Therapies
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1186/s12906-024-04691-z
- Citations
- 2
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 0.93
Funders
- Mbarara University of Science and Technology