A catalytic atroposelective Friedel–Crafts alkylation to access axially chiral C2-arylindoles <i>via</i> dynamic kinetic resolutions
An amine-catalyzed atroposelective FC alkylation of 2-arylindoles with α,β-unsaturated aldehydes via the DKR process has been developed. Various axially chiral 2-arylindoles were obtained in good yields with high enantioselectivities.
Authors
- Shan Qian (ORCID: https://orcid.org/0000-0002-9550-6885)
- Chuan Zhou
- Zhouyu Wang (ORCID: https://orcid.org/0000-0002-0704-2532)
- Xiao‐Long He (ORCID: https://orcid.org/0000-0002-2284-2060)
- Wei Li (ORCID: https://orcid.org/0000-0001-7669-1125)
- Zhiming Li (ORCID: https://orcid.org/0000-0001-5471-8462)
- Haibo Zhou (ORCID: https://orcid.org/0000-0002-7897-9912)
- Jiang Deng
- Junyuan Yan
Institutions
- Xihua University (CN)
Publication Details
- Journal
- Organic Chemistry Frontiers
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1039/d4qo01611d
- Citations
- 1
- Primary Topic
- Axial and Atropisomeric Chirality Synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.25
Funders
- National Natural Science Foundation of China
- Department of Science and Technology of Sichuan Province