Size dependent properties of Gd3+-free versus Gd3+-doped carbon dots for bioimaging application
Gd<sup>3+</sup>- free carbon dots (CDs) were synthesized by one-step solvothermal method using urea, citric acid and 3-(trifluoromethyl)aniline as precursors. Additionally, Gd<sup>3+</sup>-doped CDs were prepared by incorporating gadolinium chloride (Gd<sup>3+</sup> ions) into the synthesis. Size selection of the purified CDs was achieved through filter membranes ranging from 3 kDa to 100 kDa. The chemical composition and optical properties of the obtained samples were characterized by Energy dispersive X-ray (EDX), Fourier-transform infrared spectroscopy (FTIR), Dynamic Light Scattering (DLS), proton relaxation time measurements, Ultraviolet-visible (UV-vis) and fluorescence spectroscopies. A comparative analysis revealed a strong size-dependent behavior in the optical properties of both Gd<sup>3+</sup>-doped and Gd<sup>3+</sup>-free CDs. Furthermore, in vitro tests confirmed the non-cytotoxicity of Gd<sup>3+</sup>-doped CDs, indicating their potential applicability in biomedicine for magnetic resonance imaging (MRI) and red fluorescence-based cell and tissue imaging.
Authors
- Vladimir Lysenko (ORCID: https://orcid.org/0000-0003-1076-7064)
- Alexander N. Zaderko
- Anna Topchylo (ORCID: https://orcid.org/0009-0004-1246-8118)
- Liudmyla M. Grishchenko (ORCID: https://orcid.org/0000-0002-0342-4859)
- Konstantin Paliienko (ORCID: https://orcid.org/0000-0002-5506-3514)
- Alain Géloën (ORCID: https://orcid.org/0000-0001-7921-1254)
- Valeriy A. Skryshevsky (ORCID: https://orcid.org/0000-0003-0249-5556)
- Gauhar Mussabek
- Ruslan Mariychuk (ORCID: https://orcid.org/0000-0001-8464-4142)
- Nazym Zhylkybayeva
- Тatiana Borisova (ORCID: https://orcid.org/0000-0002-6533-1420)
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Centre National de la Recherche Scientifique (FR)
- National Academy of Sciences of Ukraine (UA)
- University of Prešov (SK)
- Al-Farabi Kazakh National University (KZ)
- Taras Shevchenko National University of Kyiv (UA)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- VetAgro Sup (FR)
- Institut Lumière Matière (FR)
- Institute of Information and Computational Technologies (KZ)
- Palladin Institute of Biochemistry (UA)
- Ecologie microbienne (FR)
Publication Details
- Journal
- Scientific Reports
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1038/s41598-024-76500-z
- Citations
- 6
- Primary Topic
- Carbon and Quantum Dots Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.70