Activating Sig-1R inhibits microvascular permeability by reducing LRRK2 expression in lipopolysaccharide-induced acute lung injury
Sig-1R activation exerts a protective effect against LPS-induced microvascular hyperpermeability by downregulating LRRK2 expression, which could lead to the development of novel therapeutic strategies for treating ALI.
Authors
- Zhenhua Zeng (ORCID: https://orcid.org/0000-0002-9509-1536)
- Menglu Shi
- Binmei Yu
- Yi Yao (ORCID: https://orcid.org/0000-0001-6452-8574)
- Lijun Weng
- Ke Peng (ORCID: https://orcid.org/0000-0003-0172-8725)
- Zhongqing Chen (ORCID: https://orcid.org/0000-0003-2482-949X)
- Yuying Li (ORCID: https://orcid.org/0000-0003-0165-8018)
- Xiang Wang (ORCID: https://orcid.org/0000-0002-2135-8576)
- Youguang Gao (ORCID: https://orcid.org/0000-0002-4861-8825)
- Tao Li (ORCID: https://orcid.org/0000-0001-8850-5836)
- Xianzhong Lin
- Tingjie Wang (ORCID: https://orcid.org/0000-0001-9238-0968)
- Cailing Guo
- Weihuang Qiu
- Bo Lin (ORCID: https://orcid.org/0009-0003-4304-0926)
Institutions
- Fujian Medical University (CN)
- Nanfang Hospital (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Chenzhou First People's Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Free Radical Biology and Medicine
- Published
- 2024-11-12
- DOI
- https://doi.org/10.1016/j.freeradbiomed.2024.11.015
- Citations
- 4
- Primary Topic
- Traditional Chinese Medicine Analysis
- Type
- article
- Field-Weighted Citation Impact
- 2.86