Synthesis, crystal structure, and insulin-mimetic activity of zinc(<scp>ii</scp>) complexes with 4-alkyl- and 4,5-dialkyl-3-hydroxythiazole-2(3<i>H</i>)-thiones as a new class of hypoglycemic agent candidates
Zinc( ii ) complexes of novel 3-hydroxythiazole-2(3 H )-thiones were synthesized, and evaluated their insulin-mimetic activities to exhibit marked antidiabetic activities.
Authors
- Ryota Saito (ORCID: https://orcid.org/0000-0003-4289-7891)
- Takeshi Miyamoto (ORCID: https://orcid.org/0000-0001-8658-9546)
- Hiroyuki Yasui (ORCID: https://orcid.org/0000-0003-3317-3947)
- Shoko Kikkawa (ORCID: https://orcid.org/0000-0002-9390-5671)
- Huiyeong Ju (ORCID: https://orcid.org/0000-0003-2961-763X)
- Yutaka Yoshikawa (ORCID: https://orcid.org/0000-0002-7177-1975)
- Shogo Sano
- Yuki Naito (ORCID: https://orcid.org/0000-0002-6468-7345)
- Isao Azumaya (ORCID: https://orcid.org/0000-0002-6651-2768)
- Masakazu Tamura
- K Maeda
- Rintaro Ohba
Institutions
- Toho University (JP)
- Kyoto Pharmaceutical University (JP)
- Kobe Women's University (JP)
- Korea Basic Science Institute (KR)
Publication Details
- Journal
- New Journal of Chemistry
- Published
- 2024-11-12
- DOI
- https://doi.org/10.1039/d4nj04035j
- Citations
- 1
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.25
Funders
- Japan Society for the Promotion of Science