Predictive and prognostic factors in patients with anaplastic lymphoma kinase rearranged early-stage lung adenocarcinoma
Clinical T1-2 N0 ALK-rearranged lung adenocarcinoma is an aggressive disease with a specific tropism for lymph nodes and the brain. High-grade tumours are predictive of nodal upstaging. Adjuvant treatment significantly improves DFS and overall survival in upstaged patients, highlighting the need for personalized preoperative staging and post-surgical management in this cohort.
Authors
- Federico Cappuzzo (ORCID: https://orcid.org/0000-0002-6295-6767)
- Lorenzo Spaggiari (ORCID: https://orcid.org/0000-0002-1068-3541)
- Filippo Tommaso Gallina (ORCID: https://orcid.org/0000-0001-5579-0837)
- Lorenzo Ferri (ORCID: https://orcid.org/0000-0003-0148-9795)
- Alberto Giovanni Busetto (ORCID: https://orcid.org/0000-0001-5284-3227)
- Isabella Sperduti
- Francesca Mazzoni (ORCID: https://orcid.org/0000-0002-5828-7839)
- Enrico Melis (ORCID: https://orcid.org/0009-0002-8076-7553)
- Nicola Martucci (ORCID: https://orcid.org/0000-0002-9563-1766)
- Luca Bertolaccini (ORCID: https://orcid.org/0000-0002-1153-3334)
- Luca Voltolini (ORCID: https://orcid.org/0000-0002-2818-859X)
- Federico Rea (ORCID: https://orcid.org/0000-0001-7988-5101)
- Fabiana Letizia Cecere (ORCID: https://orcid.org/0000-0002-6881-6773)
- Jonathan Spicer (ORCID: https://orcid.org/0000-0003-2708-1309)
- Edoardo Mercadante (ORCID: https://orcid.org/0000-0003-2101-1254)
- Giorgio Cannone (ORCID: https://orcid.org/0000-0003-4242-6168)
- Riccardo Tajè (ORCID: https://orcid.org/0009-0008-3120-3886)
- Stefano Bongiolatti (ORCID: https://orcid.org/0000-0003-2722-9270)
- Monica Casiraghi (ORCID: https://orcid.org/0000-0001-5986-7811)
- Francesco Facciolo (ORCID: https://orcid.org/0000-0002-7137-8946)
- Roni Rayes (ORCID: https://orcid.org/0000-0001-7508-020X)
- Giuseppe De Luca (ORCID: https://orcid.org/0000-0002-1984-4874)
Institutions
- University of Padua (IT)
- University of Milan (IT)
- McGill University Health Centre (CA)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- National Cancer Institute (MY)
- Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- European Institute of Oncology (IT)
Publication Details
- Journal
- European Journal of Cardio-Thoracic Surgery
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1093/ejcts/ezae406
- Citations
- 4
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 1.68