5'-Noraristeromycin Repurposing: Well-known S-Adenosyl-L-homocysteine Hydrolase Inhibitor As a Potential Drug Against Leukemia
5'-Noraristeromycin as a racemic mixture of enantiomers was found to exhibit a pronounced cytotoxic effect on leukemia cells; IC<sub>50</sub> for the Jurkat, K562, and THP-1 cell lines was 7.3, 1.3, and 3.7 μM, respectively. The general toxicity of 5'-noraristeromycin was studied in experiments on white mice upon single-dose intragastric administration; toxicometric parameters were determined, and the clinical and pathomorphological presentation of acute intoxication was studied. LD<sub>50</sub> of the substance was shown to be 63.2 (52.7÷75.8) mg/kg; LD16, 44.7 mg/kg, and LD84, 89.4 mg/kg. Administration of the substance at a dose within the studied dose range is accompanied by systemic damage to the internal organs and tissues of the experimental animals.
Authors
- Pavel Spirin (ORCID: https://orcid.org/0000-0002-0610-5079)
- Valeria Vedernikova (ORCID: https://orcid.org/0009-0002-4451-2393)
- Sergey N. Kochetkov (ORCID: https://orcid.org/0000-0002-7443-6961)
- Yu. I. Velikorodnaya (ORCID: https://orcid.org/0000-0003-2976-6352)
- Anastasia L. Khandazhinskaya (ORCID: https://orcid.org/0000-0003-1452-0253)
- Elena S. Matyugina (ORCID: https://orcid.org/0000-0002-4981-7316)
- В. С. Прасолов
- Aleksandr Vladimirovich Gorshenin (ORCID: https://orcid.org/0000-0002-6049-8133)
- O. N. Novikova (ORCID: https://orcid.org/0000-0002-9753-1881)
- M. D. Krengauz
Institutions
- Engelhardt Institute of Molecular Biology (RU)
- Moscow Institute of Physics and Technology (RU)
- Moscow Power Engineering Institute (RU)
- Genetic Technologies (Australia) (AU)
- Moscow Aviation Institute (RU)
- Federal Medical-Biological Agency (RU)
Publication Details
- Journal
- Acta Naturae
- Published
- 2024-11-12
- DOI
- https://doi.org/10.32607/actanaturae.27443
- Primary Topic
- Cancer therapeutics and mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00