A Metabolome Wide Association Study of Fruit and Vegetable Consumption and Associations with Cardiovascular Disease Risk Factors: The International Study of Macro-/Micronutrients and Blood Pressure (INTERMAP) Study
We identified <sup>1</sup>H NMR-derived urinary metabolites associated with fruit and vegetable consumption, consistent and reproducible between urine collections and across populations. A higher fruit and vegetable-related metabolite score showed associations with lower systolic BP and BMI, mainly mediated by citrate, but would need confirmation in further studies.
Authors
- Paul Elliott (ORCID: https://orcid.org/0000-0002-7511-5684)
- Elaine Holmes (ORCID: https://orcid.org/0000-0002-0556-8389)
- Linda M. Oude Griep (ORCID: https://orcid.org/0000-0001-7697-7473)
- Timothy M. D. Ebbels (ORCID: https://orcid.org/0000-0002-3372-8423)
- Linda Van Horn (ORCID: https://orcid.org/0000-0002-1362-5806)
- Gary Frost (ORCID: https://orcid.org/0000-0003-0529-6325)
- Elena Chekmeneva (ORCID: https://orcid.org/0000-0003-1807-2398)
- Queenie Chan (ORCID: https://orcid.org/0000-0001-9278-230X)
- Martha L. Daviglus (ORCID: https://orcid.org/0000-0002-6791-8727)
Institutions
- Northwestern University (US)
- Murdoch University (AU)
- University of Illinois Chicago (US)
- Office of Minority Health (US)
- MRC Biostatistics Unit (GB)
- MRC Epidemiology Unit (GB)
- Imperial College London (GB)
Publication Details
- Journal
- Journal of Nutrition
- Published
- 2024-11-12
- DOI
- https://doi.org/10.1016/j.tjnut.2024.11.004
- Citations
- 4
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Amgen
- National Institute for Health and Care Research
- Department of Health and Social Care
- Imperial College London
- National Institutes of Health
- NIHR Imperial Biomedical Research Centre
- NIHR Cambridge Biomedical Research Centre
- National Heart, Lung, and Blood Institute