Maintenance immunosuppressive therapy in liver transplantation: results from CESIT study, an Italian retrospective cohort study
The study highlights a shift over time in postliver transplant therapeutic patterns, favouring the use of tacrolimus in combination with mycophenolate or mTORi, rather than monotherapy. Moreover, a potential association between tacrolimus monotherapy and increased mortality in the cirrhosis cohort was identified. Further research is warranted to investigate these findings more deeply and to optimise treatment strategies for liver transplant recipients.
Authors
- Silvia Pierobon (ORCID: https://orcid.org/0000-0001-9028-6580)
- Valeria Belleudi (ORCID: https://orcid.org/0000-0002-8286-443X)
- Donatella Garau
- Martina Zanforlini
- Marina Davoli (ORCID: https://orcid.org/0000-0003-4521-032X)
- Massimo Cardillo (ORCID: https://orcid.org/0000-0002-2776-2297)
- Alessandro Cesare Rosa (ORCID: https://orcid.org/0000-0001-6653-9605)
- Antonio Addis (ORCID: https://orcid.org/0000-0003-0962-9959)
- Stefania Spila Alegiani (ORCID: https://orcid.org/0000-0003-0656-1346)
- Marco Finocchietti
- Marco Massari (ORCID: https://orcid.org/0000-0001-8442-4238)
- Arianna Bellini (ORCID: https://orcid.org/0000-0002-4558-0921)
- Stefano Ledda
- Silvia Trapani (ORCID: https://orcid.org/0000-0002-8854-7144)
- Olivia Leoni (ORCID: https://orcid.org/0000-0002-6906-2424)
- Lucia Masiero (ORCID: https://orcid.org/0000-0002-6552-6228)
- Eliana Ferroni (ORCID: https://orcid.org/0000-0003-4803-2004)
Institutions
- Istituto Superiore di Sanità (IT)
- Regione del Veneto (IT)
- Agenzia Regionale Parchi (IT)
- Azienda Ospedale - Università Padova (IT)
- Progemisa (IT)
- Lombardia Informatica (Italy) (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- BMJ Open
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1136/bmjopen-2024-087373
- Citations
- 2
- Primary Topic
- Organ Transplantation Techniques and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- Agenzia Italiana del Farmaco, Ministero della Salute